Abstract

SA.08.03

Antioxidant therapy influence on antioxidant protection in traumatic vitreous hemorrhage (experimental study)

Kravchuk E. A., Kiseleva T. N.
State Rsearch Institute of Eye Diseases, Russian Academy of Medical Sciences, Moscow

Objective: To establish the antioxidant efficacy of a new antioxidant drug «CDR-30» using experimental model of traumatic vitreous hemorrhage.
Methods: The study was carried out on 16 rabbits with traumatic hemophthalmia. The basic group (10 rabbits) was treated with 1% - 0,5 ml «CDR-30» parabulbar injections in a day. The control group (10 rabbits) was treated with isotonic solution parabulbar injections in dosage 0,5 ml in a day. The treatment lasted within two weeks. Blood serum, lacrimal fluid and humor aqueous were used as material for the study. Biochemical indices: the relation between malondialdehyde/ scavenger enzyme (MDA/SE) was determined on 1^st, 7^th and 14^th day of the experiment.
Results: In the basic group relation MDA/SE was increased in lacrimal fluid on 1^st day (3,9), and decreased on the 7^th and the 14^th day of the experiment (1,1 and 1,0 accordingly). In the control group relation MDA/SE in lacrimal fluid reached the maximal data on the 1st day and hadn’t practically changed in a course of the study. Dynamics of relation MDA/SE in humor aqueous in both groups was practically identical. In the basic group relation MDA/SE in blood serum was gradually decreased during the study (2,7; 2,4; 1,9 on the 1^st, 7^th and 14^th day of the experiment accordingly). In the control group relation MDA/SE was significantly increased until the end of the study.
Conclusions: Local administration of a new antioxidant drug «CDR-30» in parabulbar injections has a positive influence on biochemical processes in ocular tissues in traumatic vitreous hemorrhage.

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