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AbstractP 014 Central retinal thickness measurement obtained with HD-OCT and Stratus-OCT® in healthy subjects and glaucoma patients Hirn C., Aue A., Geitzenauer W., Leydolt C., Schmidt-Erfurth U., Vass C.
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria Objective: Fast scanning high definition optical coherence tomography (HD-OCT) enables to visualize single retinal layers. Aim of the study was to compare central retinal thickness measured using Stratus-OCT® and HD-OCT together with a newly developed algorithm for automated segmentation and quantification of retinal layers.
Methods: Mean central retinal thickness was measured in healthy subjects and glaucoma patients at different stages of disease using Stratus-OCT®. HD-OCT raster scanning of a 20°x20° field was performed at a resolution of 512x128x1024 voxels. Using a specially developed algorithm single retinal layers were detected and quantified. Retinal thickness was defined as distance between membrane limitans interna and the inner/outer segments junction according to Stratus-OCT® standards. The central 1.5mm radius of each scan was subdivided in 5 fields according to Stratus-OCT® retinal maps: central 1mm area (0.5mm radius) as well as four outer fields. To reduce inter-scan fluctuation of the Stratus-OCT® scans, the mean value of three measures was calculated. Statistical analysis was performed using paired t-test.
Results: Mean central retinal thickness was 213µm in the inner 0.5 radius and 277µm-292µm in the outer fields for HD-OCT measures and 209µm und 270µm282µm for Stratus-OCT® measures. Mean central retinal thickness was 4µm-13µm higher in HD-OCT measures. This difference was statistically significant in all fields except the central 1mm area (p<0.001 and p=0.211, respectively).
Conclusions: Central retinal thickness measurement is possible using HD-OCT with the automated layer segmentation, although the results are by 1.9%-4.7% higher than in Stratus-OCT® measurement.
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