Abstract

P 001

Color doppler imaging of ocular hemodynamics in Sturge-Weber syndrome in pediatric patients

Jonescu-Cuypers C. P.^1,2, Harris A.², Siesky B.², Seitz B.¹, Gatzioufas Z.¹, Zion I. B.², Neely D. E.^2
1Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes, Homburg/Saar; ²Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA

Objective: Sturge-Weber syndrome (SWS) is frequently associated with early onset glaucoma, ipsilateral to the facial angioma. The exact cause of glaucoma in SWS is poorly understood and difficult to treat. The purpose of this study is to investigate the ocular hemodynamics of children with Sturge-Weber associated glaucoma using color Doppler imaging (CDI) techniques.
Methods: Prospective study of 10 pediatric patients, age 5.5 years (SD 4.9) with unilateral Sturge-Weber associated glaucoma. CDI was used to measure the peak systolic velocity (PSV) and the end diastolic velocity (EDV) and resistive Index (RI) of both the ophthalmic artery (OA) and central retinal artery (CRA) in the glaucomatous eyes and the contra lateral normal eyes. Statistics were performed using the SPSS 11.0 Software package (SPSS Inc., Chicago, IL, USA).
Results: In the glaucomatous eye, OA PSV was 25,45 cm/s, OA EDV 6,65 cm/s, CRA PSV 7,03 cm/s, CRA EDV 1,75 cm/s, OA RI 0,76 and CRA RI 0,75. In the control eyes, OA PSV was 26,04 cm/s, OA EDV 7,67 cm/s, CRA PSV 7,86 cm/s, CRA EDV 2,33 cm/s, OA RI 0,73 and CRA RI 0,71. EDV of the CRA were significantly lower in the glaucomatous eyes of children with SWS when compared to the normal contra lateral eyes (p=0.035). No significant differences were found in the measurements of OA blood flow.
Conclusions: The glaucomatous eye of children with SWS exhibits hemodynamic compromise with lower blood flow compared to the contra lateral eye. This finding may lend support to vascular theories of pathogenesis in Sturge-Weber associated glaucoma.

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