Abstract

SA.16.05

The role of 5-FU in the protection of filtering bleb

Mandic Z., Bencic G., Zoric-Geber M., Novak-Laus K.
University Department of Ophthalmology, University Hospital "Sestre milosrdnice" Zagreb, Croatia

Objective: Operative trauma during cataract extraction on patients with previous trabeculectomy predisposes to bleb failure and survival of the filtering bleb. This study was carried out to evaluate the protective effect of subconjunctival 5-FU application to help preserve functioning trabeculectomy blebs.
Methods: The first study group of patients included 18 eyes with preexisting bleb from trabeculectomy, that underwent uneventful phacoemulsification. At the end of the operation they received 5-FU subconjunctivaly. The second group of patients included 22 eyes with filtering bleb from trabeculectomy, that underwent phacoemulsification without the application of antimetabolites. Comparison of IOP, visual acuity (VA) and number of antiglaucoma medications were analyzed between the two groups.
Results: There was a significant defference in mean change of glaucoma treatment between the groups at 10 months postoperatively. Worsening of IOP in first group with application of 5-FU was seen in 15.5% and in 28.5% in group without antimetabolites.
Conclusions: Application of 5-FU at the end of cataract operation may reduce fibroblast proliferation and protect trabeculectomy bleb.

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