Abstract

P 004

Contrast sensitivity and ocular perfusion in patients with normal tension glaucoma

Kaup M.¹, Plange N.¹, Remky A.¹, Arend K. O.^2
1Augenklinik, Universitätsklinikum Aachen, ²Augenzentrum Alsdorf

Objective: Previous studies revealed disturbed retinal perfusion and decreased contrast sensitivity in patients with normal tension glaucoma (NTG). To evaluate the correlation of contrast sensitivity with ocular perfusion in patients with NTG.
Methods: Twenty-four patients (mean age 55±12 years) with NTG without any topical therapy were included in this study. Static contrast sensitivity (in log units) was performed at four spatial frequencies: 3, 6, 12 and 18 cycles per degree (cpd) (CSV 1000, Vector Vision, USA). In video fluorescein angiograms (Scanning Laser Ophthalmoscope, Rodenstock) arteriovenous passage time was examined by means of digital image analysis using dye dilution curves.
Results: Patients with NTG showed an AVP of 2.1±0.5 s. Contrast sensitivity at 3 cpd was 1.5±0.3 log units, at 6 cpd 1.7±0.2 log units, at 12 cpd 1.3±0.3 log units and at 18 cpd 0.9±0.3 log units. AVP was significantly correlated with contrast sensitivity (6cpd: r=-0.52, p<0.01, 12 cpd: r=-0.45, p< 0.05, 18 cpd: r=-0.52, p<0.01).
Conclusions: Patients with NTG showed a significant correlation of contrast sensitivity with the retinal perfusion. Apart from the reduction of intraocular pressure, the aim of glaucoma therapy should be an improvement of ocular perfusion, which might lead to a better function.

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