Abstract

P 164

Spatial and temporal association between neuroretinal rim loss and retinal nerve fiber layer thickness measurements in patients with optic disc hemorrhages

Lämmer R.¹, Nguyen T. K.^1,2, Nguyen N. X.³, Horn F. K.¹, Jünemann A. G. M.¹, Mardin C. Y.¹ (Erlanger Glaukomforschung im SFB 539)
¹Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland; ²Augenklinik Ho Chi Minh Stadt, Vietnam; ³Universitätsaugenklinik Tübingen, Abteilung II (Pathophysiologie des Sehens und Neuro-Ophthalmologie), Tübingen, Deutschland

Objective: The purpose of the study was to investigate the ability of scanning laser polarimetry to detect thinning of the retinal nerve fiber layer after occurrence of optic disc hemorrhages. Spatial and temporal association between nerve fiber layer and neuroretinal rim loss was evaluated.
Methods: Seventeen eyes of 15 patients with optic disc hemorrhage were recruited from the Erlangen Glaucoma Registry for this study. All included patients received annual detailed examination for glaucoma. Mean follow-up time was 5.0±1.4 years. Change in neuroretinal rim area was evaluated by planimetry using optic disc photographs and retinal nerve fiber layer thickness was analyzed by scanning laser polarimetry. Baseline was defined as the measurement one year before the occurrence of optic disc hemorrhage. Standard parameters, global measurements and sector analysis were performed and association between nerve fiber layer and neuroretinal rim loss was evaluated.
Results: From all investigated parameters The Number had the highest diagnostic power to detect progressive change after occurrence of optic disc hemorrhage. Higher values were observed already at the time point at which the hemorrhage occurred but differences were statistically significant not before follow-up of 2 years or more. Retinal nerve fiber layer thickness and neuroretinal rim area globally and in the analyzed sectors decreased and parapapillary atrophy increased during the follow-up period. Correlation coefficient between nerve fiber and neuroretinal rim loss over time was r=0.46, p=0.08.
Conclusions: Scanning laser polarimetry might detect localized nerve fiber loss after optic disc hemorrhage but repeated measurements and long-term follow-up are required.
Supported by Deutsche Forschungsgemeinschaft SFB 539 “Glaukome und Pseudoexfoliationssyndrom“
Supported by DAAD (project A/03/19670)

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