Abstract

P 065

Correlation of optical coherence tomography, scanning laser polarimetry and static perimetry in neuro-ophthalmologic optic atrophies

Staubach F., Jehle T., Cotto A., Lagrèze W. L.
Universitäts-Augenklinik Freiburg

Objective: Nerve fibre defects in optic atrophies manifest as structural and functional deficits. Structural deficits can be quantified by measuring the retinal nerve fibre layer (RNFL) thickness with optical coherence tomography (OCT) or scanning laser polarimetry (GDx), functional deficits with static perimetry. The interrelation between these methods has been characterized for glaucomatous atrophies. This study aims at describing the correlation of the stated methods in neuro-ophthalmologic optic atrophies.
Methods: Of 27 patients 38 eyes were examined with the Stratus-OCT [mean RNFL thickness, "3.4" parameter], 42 with the GDxVCC [mean RNFL thickness, "SNIT" parameter], and 44 with the Octopus 101 [mean defect, MD]. All cases of optic atrophy represented inactive end stages, the original causes being compressive, ischaemic, inflammatory, or hereditary. Linear regressions were calculated for correlations between OCT, GDx and Octopus.
Results: The coefficient of determination between OCT and GDx was r2=0,40 (p<0,0001), between OCT and Octopus r2=0,33 (p<0,0005), and between GDx and Octopus r2=0,62 (p<0,0001).
Conclusions: In neuro-ophthalmologic optic atrophies, RNFL thickness measurements with optical coherence tomography and scanning laser polarimetry correlate with one another and with static perimetry. The degree of a neuro-ophthalmologic optic atrophy can thus be estimated with OCT and GDx. Both methods can therefore amend routine diagnostics by providing objective as well as quantitative parameters.

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