Abstract

P 159

Dependency of ocular pulse amplitude from application of tropicamide in healthy subjects

Link B., Tornow R. P., Jünemann A.
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg, Erlangen, Erlangen Glaucoma Research SFB 539

Objective: Since the introduction of the dynamic contour tonometry (DCT), the ocular pulse amplitude (OPA) has gained an increasing importance in glaucoma diagnosis. A negative influence of tropicamide on the retinal perfusion has been demonstrated previously. Aim of this study is to evaluate the influence of tropicamide on the OPA.
Methods: The intraocular pressure (IOP) and the ocular pulse amplitude (OPA) were measured with the DCT (SMT Swiss Microtechnology AG) in 14 eyes of 7 healthy subjects before, and 15 and 45 minutes after pupil dilatation with tropicamide. The mean of two corresponding measurements entered statistical analysis.
Results: Before pupil dilatation, IOP was 16.5±2.2 mmHg, OPA 2.8±0.7 mmHg. 15 min after instillation of tropicamide, IOP was 16.6±2.3 mmHg, OPA 3.1±0.6 mmHg. 45 min after instillation of tropicamide, IOP was 17.1±2.1 mmHg, OPA 2.7±0.8 mmHg. There is a statistically significant difference between OPA before and 15 min after instillation of tropicamide (p=0.02).
Conclusions: Our results show a significant influence of tropicamide on the ocular pulse amplitude. Reasons may be a reduced retinal blood-flow or a change in measurement dynamics due to a smaller area of the iris diaphragm. This needs to be clarified in further investigations.

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