Abstract

SA.15.10

Uveal and capsular biocompatibility of two Acrylic Intraocular Lenses in patients with non-infectious uveitis – prospective randomized study

Rösel M., Heinz C., Heiligenhaus A.
Department of Ophthalmology, St. Franziskus-Hospital, Muenster

Objective: Cataract formation is a common complication in uveitis patients. In this study, a hydrophobic and a hydrophilic acrylic intraocular lens (IOL) were compared with respect to uveal and capsular biocompatibility, visual outcome and postoperative complications.
Methods: Prospective, randomized study with 56 patients (62 eyes) with inactive non-infectious uveitis, who underwent phacoemulsification with IOL implantation. Patients either received an AcrySof^TM (group 1) or an Akreos adapt^TM (group 2) IOL. Follow-up was scheduled at 1, 3 and 6 months postoperatively. Best-corrected visual acuity (BCVA), anterior (ACO) and posterior capsule opacification (PCO) laser-flare photometry (Kowa FC 100, Japan), anterior chamber cells and posterior synechiae were determined.
Results: While 29 eyes received an AcrySof^TM IOL, another 33 got an Akreos Adapt^TM IOL. The groups did not differ with respect to anatomic type of uveitis, immunosuppression, associated systemic disease and intraoperative manipulation (e.g. synechiolysis, membrane removal, sphincterotomy). BCVA at 6 month increased in group 1 from 0.824 logMAR to 0.352, and in group 2 from 0.739 to 0.238 (p=0.237). The number of anterior chamber cells did not differ between the groups. Laser-flare photometry levels after 1 month were higher in group 1 than in group 2 (p=0.063) and a slight difference was still found after 6 month (p=0.199). The number of cell deposits on the anterior IOL surface in group 1 were slightly higher than in group 2 (p=0.181). ACO rates did not differ between the groups (p=0.41). PCO rates and the number of Nd:YAG laser capsulotomies (p=0.140) were slightly higher in group 2 than in group 1. At 6 months postoperatively, posterior synechiae were noted in one patient in group 1, and in no patient in group 2 (p=0.547).
Conclusions: This study demonstrates that both of the acrylic IOLs used had good capsular and uveal biocompatibility, leading to significant improvement of BCVA in patients with non-infectious uveitis. While the uveal biocompatibility was better with the hydrophilic acrylic IOL, the PCO rate was slightly better with the hydrophobic acrylic IOL.

Copyright: Porstmann Kongresse GmbH. All rights reserved. Impressum, Disclaimer.