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AbstractSA.10.09 The structure of lymph-proliferative neoplasms and the role of cytogenetic investigation in differential diagnosis of marginal-zone lymphomas in patients with orbital and ocular adnexa lesions Vit V. V., Iakovenko T. O., Zborovska O. V.
The Filatov Institute of Eye Disease and Tissue Therapy, Odessa, Ukraine Objective: To define differential-diagnostic significance of cytogenetic peculiarities of marginal zone lymphoma (further LMZ) in patients with orbital and ocular adnexa lesions.
Methods: 48 fixed by formalin and suffused by paraffin neoplasms of orbit and ocular adnexa were investigated. Morphologic, immunohystochemical, cytogenetic investigation carried out. While defining the cytogenetic peculiarities, the following figures were studied: mitotic tumour activity, pathologic, physiologic mitoses quantity, and the quantity of mitoses of the initial stage of division. Diagnostic test on the basis of cytogenetic rate of mitotic index with ROC-plotting was used.
Results: Reactive lymphoid hyperplasia among investigated lymph-proliferative neoplasms amounts in 29,2% (14 patients), lymphoma in 70,8% 934 patients). Marginal zone lymphomas prevailed in our studies (73%, (25 patients)). 16% (4 patients) of them CD5+LMZ. Diffuse large cell B-cell lymphoma was diagnosticated in 12 % (4 patients), Follicle lymphoma in 6% (2 patients). Mantle sell lymphoma, lymphocytic lymphoma and plasmocytoma form 3% (1 patient). Mitotic index is higher in CD5+LMZ 0,17±0,06, and lower in CD5-LMZ 0,08±0,04 (p=0,047).Statistically reliable results have not been obtained in evaluating the quantity of pathologic and physiologic mitoses, and mitoses at the initial stage of division.
Conclusions: LMZ prevail among orbital and ocular adnexa lymphomas (73%), with CD5+type constituting 16% of all LMZ. Mitotic index of CD5-LMZ of orbit and ocular adnexa is reliably higher than that of CD5-LMZ. This index can be used in carrying differential diagnosis between CD5+ and CD5- LMZ in the system of morphological and immunohystochemical research. For the rational use of differential diagnostic index in practice there has been suggested ROC-test, inflexion 0,1% (ROC=0,96 (0,73-0,99) of positive test.
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