Abstract

SO.11.12

The comparative analysis of application of the intravitreal triamcinolone and diprospan in the treatment of the patients with central chorioretinitis

Bezditko P. A., Vlasko H. V., Mukha I. D.
Kharkov State Medical University, Department of Ophthalmology, Ukraine

Objective: Learning of clinical efficacy of the intravitreal triamcinolone and diprospan in the treatment of patients with central chorioretinitis.
Methods: The study included 30 patients (36 eyes) - 17 men and 13 women in the age from 17 to 45 years. All patients were observed in an exudation phase. The first group (15 patients - 18 eyes) got an intravitreal injection of triamcinolone acetonide at the dose of 4 mg in 0.1 ml twice with an interval of two months. The second group (15 patients - 18 eyes) got an intravitreal injection of diprospan at the dose of 0.7 mg in 0.1 ml twice with an interval of two months. Examination of patients included: detection of visual acuity (without correction, with correction), ophthalmoscopy direct and revertive, ophthalmobiomicroscopy, perimetry, tonometry, Haidinger’s phenomenon. The evaluation of clinical efficacy of drugs was carried out with the count of dynamics of visual functions, level of intraocular pressure, intra- and after-operational complications, decreases of exudation in the vitreous body, microhemorrage quantities.
Results: After the course of treatment visual acuity increased for 52,4% with patients of the first group and for 38,6% with the second group on the average in 0,2±0,05. Intraocular pressure was within normal and ranged between 17 and 24 mmHg for both groups. The decrease of macular oedema, microhemorrage quantities were observed in 42,76% of patients of the first group and in 28,57% of patients of the second group. None of patients had an increase of a postoperative endophthalmitis, development posterior subcapsular cataracts, retinal detachment.
Conclusions: Intravitreal injection of corticosteroids in complex treatment of chorioretinitis is safe, it improves vision, reduces or stabilizes macular oedema. Implementation of triamcinolone acetonide in the same dose as diprospane is more effective due to quicker absorption and it enables to increase the quality of chorioretinitis treatment.

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