Abstract

DO.24.09

Comparison of 5 cases with intraocular medulloepithelioma

Holdt M., Bölöni R., Jurklies C., Bornfeld N.
Abteilung für Erkrankungen des hinteren Augenabschnitts, Zentrum für Augenheilkunde, Universitätsklinikum Essen

Objective: Several single case reports of patients with intraocular medulloepithelioma are published. The comparison of 5 patients of our hospital shall present the similarities and varieties.
Methods: Case history, examination reports, therapeutical procedure and histological results will be compared.
Results: All 5 cases are children at the age of 3 to 11 years. The tumor was strict unilateral. Red eye and decrease of visual acuity were the most common symptoms in the beginning. All tumors were located at the ciliary body, in 4 cases with seeding in the anterior chamber, in 2 cases with vitreous seeding, in 1 case with metastasis at the posterior pole. Secondary glaucoma was observed in 4 cases, 1 patient was multiple cyclophotocoagulated. 2 patients with luxatio lentis were treated with ppL. In 1 case a biopsy of the anterior chamber was necessary. Finally all eyes were enucleated. Histological there were medullary epithelial cells with different grading. In 1 case we saw a metastasis with a high rate of proliferation. A higher malignant grade was supposed in this case.
Conclusions: The comparison presents in all 5 cases a strict unilateral intraocular medulloepithelioma. In 4 cases there was a severe decrease of visual acuity up to blindness and an arguable tumor progression. Enucleation was necessary in all 5 cases. Only histological findings ensured the diagnosis of a medulloepithelioma. There was no extraocular tumor affection. The children developed no severe complications.

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