Abstract

SO.05.08

Levels of substance P and secretoneurin in vitreous aspirates

Stemberger K.¹, Troger J.¹, Fischer-Colbrie R.², Kremser B.¹, Schmid E.¹, Kralinger M.¹, Kieselbach G.^1
1Universitätsklinik für Augenheilkunde und Optometrie, Medizinische Universität Innsbruck; ²Institut für Pharmakologie, Medizische Universität Innsbruck

Objective: To detect the levels of substance P (SP) and secretoneurin (SN) in vitreous aspirates of patients with various vitreoretinal diseases.
Methods: Vitreous was aspirated from patients undergoing pars plana vitrectomy for macular foramina, diabetic retinopathy (DR), active proliferative DR (PDR), inactive PDR, rhegmatogenous retinal detachment, proliferative vitreoretinopathy (PVR) and epiretinal gliosis and the concentration of SP and SN was detected by a highly sensitive radioimmunoassay.
Results: Both SP and SN were detectable in each sample and the concentration of SN was in general higher than that of SN. There was a significant reduction of SN in patients with active PDR and the levels of both peptides were elevated in patients with rhegmatogenous retinal detachment whereas there were normal concentrations of both peptides in patients with PVR and epiretinal gliosis.
Conclusions: Although both peptides exert proangiogenic properties, the reduced levels of SN and normal values of SP in active PDR indicate that the peptides are not involved in the pathogenesis of neovascularizations in PDR. An involvement in the pathogenesis of PVR can not be excluded despite of the normal concentrations.

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