Abstract

FR.18.04

Evaluation of animal models with hereditary retinal disease

Tanimoto N.
Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, Tübingen

The pathophysiology of hereditary retinal diseases is not fully established yet, because they are rare and an in-depth analysis beyond the clinical examination can not be performed in patients. In accordance with major advances in our understanding of the molecular bases of retinal dysfunctions and degenerations, animal models carrying the identical genetic defects are of great importance for the study of such diseases even when the rate of occurrence is low.
The in vivo examination of animal models can be well compared with those in patients, because the diagnostic techniques such as electroretinography and scanning-laser ophthalmoscopy are common in both fields. The findings are well complemented by in vitro data.
This presentation focuses on the correlation between structure and function in animal models with hereditary retinal degenerations. In particular, the use of functional and morphological diagnostics to facilitate phenotyping and understanding of disease mechanisms is demonstrated.

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